A study of prophylactic low dose ketamine and granisetron for prevention of shivering during spinal anesthesia

Spinal anesthesia significantly results in shivering and hypothermia as unwanted effect. Shivering increases oxygen consumption which may be deleterious patients who have low cardiac pulmonary reserve. We conducted this study to evaluate the efficacy of Ketamine Granisetron for prevention under spinal anesthesia. In randomized prospective study, 90 Patients aged 18-60 years ASA physical status I & II undergoing various surgical procedures were included allocated alternately one 3 groups; Normal saline (Group P), 0.25mg/kg K) 40μg/kg G). Incidence shivering, effect on haemodynamics, nausea, vomiting, sedation recorded. The comparable terms demographic variables, baseline temperature, median level sensory blockade. was present 10 (33%), (10%), 1 (3%) respectively Group P, G, K. 8 (26%) experienced at Grade higher than Groups G K (P = 0.0003). None sedated P. seen cases group, most them grade 2 only (P<0.05). No hallucination any patients. Low dose ketamine are effective comparison placebo during is more granisetron.