A Statistical DOI Estimation Algorithm for a SiPM-Based Clinical SPECT Insert

A prototype clinical brain single-photon emission computed tomography (SPECT) insert has been designed for use in simultaneous SPECT/MRI. The system utilizes novel slit-slat collimators which, like pinhole collimators, suffers from parallax errors due to the large incident angle of photons. statistical algorithm developed determine depth-of-interaction (DOI) with a view improving image performance. importance DOI correction was demonstrated using Monte Carlo simulation. This simulation also indicated that four layers ( $3 \times 1.5\, \textrm {mm} + 3.5\, {mm}$ ) may be sufficient. improvement event localization on single detector before implementing full where some limitations close readout plane were observed. Nevertheless, enabled rejection poorly localized events improved resolution reconstructed line sources.