A spin-labelling Nobel?

Hepatic arterial spin labelling MRI: an initial evaluation in mice

The development of strategies to combat hepatic disease and augment tissue regeneration has created a need for methods to assess regional liver function. Liver perfusion imaging has the potential to fulfil this need, across a range of hepatic diseases, alongside the assessment of therapeutic response. In this study, the feasibility of hepatic arterial spin labelling (HASL) was assessed for the ...

Application of Arterial Spin Labelling in Detecting Retinal Ischemia

Purpose Here, we have tried to quantify the chorioretinal blood perfusion in patients who are clinically identified to be suffering from retinal ischemia using arterial spin labelling (ASL) MRI. Method Four participants, diagnosed with retinal ischemia based on their structural OCT and angiography test, were then scanned using anatomical MRI as well as ASL. We optimized MR parameters to maxim...

A Nobel for Smell

Nobel citation makes clear, Buck and Axel not only and Molecular Pharmacology solved the mystery of the olfactory receptors but, in a University of California, San Francisco remarkable series of subsequent experiments, outlined San Francisco, California 94143 the basic organizational principles of the vertebrate ol2 Howard Hughes Medical Institute factory system. More generally, the discovery o...

Properties of polyethylene glycol/cyclodextrin hydrogels revealed by spin probes and spin labelling methods.

The properties of a gel consisting of a covalent network formed by the reaction of isocyanate end-capped polyethylene glycol (PEG) with β-cyclodextrin, were investigated by EPR spectroscopy. Spin-labelled cyclodextrin was incorporated into the cross-link points of the gel and at the chain ends. The dynamics of the gel fibres as reported by the spin label, was found to be sensitive to the H-bond...

A Nobel Ideal