منابع مشابه
Completion of a Programmable DNA-Binding Small Molecule Library.
Hairpin pyrrole-imidazole (Py-Im) polyamides are programmable oligomers that bind the DNA minor groove in a sequence-specific manner with affinities comparable to those of natural DNA-binding proteins. These cell-permeable small molecules have been shown to enter the nuclei of live cells and downregulate endogenous gene expression. We complete here a library of 27 hairpin Py-Im polyamides which...
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The identification of small molecules that inhibit the sequence-specific binding of transcription factors to DNA is an attractive approach for regulation of gene expression. Hypoxia-inducible factor-1 (HIF-1) is a transcription factor that controls genes involved in glycolysis, angiogenesis, migration, and invasion, all of which are important for tumor progression and metastasis. To identify in...
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Label-free technologies are mostly used for detection of biomolecular interactions between proteins or other macromolecules. Characterization of small molecule to protein binding has often been a challenge because label-free signal depends on molecular weight of the analyte and analyte-to-target molecular weight ratio. In this study we show that Nanopore Optical Interferometry (NPOI) can be use...
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ژورنال
عنوان ژورنال: Biopolymers
سال: 2015
ISSN: 0006-3525
DOI: 10.1002/bip.22660