A single-cell platform for reconstituting and characterizing fatty acid elongase component enzymes
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چکیده
منابع مشابه
Combinatorial Effects of Fatty Acid Elongase Enzymes on Nervonic Acid Production in Camelina sativa
Very long chain fatty acids (VLCFAs) with chain lengths of 20 carbons and longer provide feedstocks for various applications; therefore, improvement of VLCFA contents in seeds has become an important goal for oilseed enhancement. VLCFA biosynthesis is controlled by a multi-enzyme protein complex referred to as fatty acid elongase, which is composed of β-ketoacyl-CoA synthase (KCS), β-ketoacyl-C...
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Very long chain fatty acids (VLCFAs) are involved in plant development and particularly in several cellular processes such as membrane trafficking, cell division and cell differentiation. However, the precise role of VLCFAs in these different cellular processes is still poorly understood in plants. In order to identify new factors associated with the biosynthesis or function of VLCFAs, a yeast ...
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The mechanism of the biological oxidation and synthesis of fatty acids has largely been elucidated during the past few years through work in several laboratories (l-7). This work resulted in the complete confirmation of Knoop’s B oxidation theory and of the main conclusions derived from the early work of Dakin and Embden. Perhaps one of the most important aspects of the recent work is the demon...
متن کاملThe fatty acid elongase Bond is essential for Drosophila sex pheromone synthesis and male fertility
Insects use a spectacular variety of chemical signals to guide their social behaviours. How such chemical diversity arises is a long-standing problem in evolutionary biology. Here we describe the contribution of the fatty acid elongase Bond to both pheromone diversity and male fertility in Drosophila. Genetic manipulation and mass spectrometry analysis reveal that the loss of bond eliminates th...
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ژورنال
عنوان ژورنال: PLOS ONE
سال: 2019
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0213620