A Simple and High Throughput Methodology for Simultaneous Determination of Levodopa and Carbidopa

Parkinson's disease (PD) is a degenerative disorder of the central nervous system. The motor symptoms PD result from death dopamine-generating cells in region mid brain and dopamine precursor levodopa (L-Dopa) used for treatment. Carbidopa (Car) administered association with L-Dopa pharmaceutical formulation as an inhibitor on decarboxylase activity. Thus, their simultaneous determination great importance because co-existence preparations. Present study deals simple method development voltammetric Car at pencil graphite electrode (PGE) via monitoring reduction peak second oxidation Car. sensitivity was found comparable to other methods depending sophisticated modifications limits detection were calculated sub micromolar levels.