A sighted man with non-24-hour sleep-wake syndrome shows damped plasma melatonin rhythm

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Non-24-Hour Sleep-Wake Disorder Revisited – A Case Study

The human sleep-wake cycle is governed by two major factors: a homeostatic hourglass process (process S), which rises linearly during the day, and a circadian process C, which determines the timing of sleep in a ~24-h rhythm in accordance to the external light-dark (LD) cycle. While both individual processes are fairly well characterized, the exact nature of their interaction remains unclear. T...

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Non-24-Hour Sleep–Wake Rhythm Disorder in the Totally Blind: Diagnosis and Management

Several aspects of human physiology and behavior are dominated by 24-h circadian rhythms with key impacts on health and well-being. These include mainly the sleep-wake cycle, vigilance and performance patterns, and some hormone secretions. The rhythms are generated spontaneously by an internal "pacemaker," the suprachiasmatic nuclei within the anterior hypothalamus. This master clock has, for m...

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Comorbidity of Non-24-hour Sleep-wake Syndrome and Seasonal Affective Disorder in a Young Man: a Case Report

Objective: Few clinical reports have described in detail the comorbidity of seasonal affective disorder (SAD) and non-24-hour sleep-wake syndrome (non-24-SW). Both SAD and non-24-SW are thought to be caused by the interplay between internal clock dysfunction and insufficient external time cues. The aim of this study is to present and discuss in detail a subtype of psychiatric comorbidity and it...

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Non-24-hour sleep–wake syndrome improved by low-dose valproic acid: a case report

A woman was diagnosed with non-24-hour sleep-wake syndrome and depressive symptoms. Her depressive symptoms did not respond to standard doses of several antidepressants or mood stabilizers. Furthermore, her sleep-wake cycle remained non-entrained despite treatment with a melatonin-related drug, vitamin B12, and phototherapy. Ultimately, her sleep-wake rhythm was restored to a 24-hour pattern wi...

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Effect of aripiprazole on non-24-hour sleep–wake rhythm disorder comorbid with major depressive disorder: a case report

BACKGROUND Patients with non-24-hour sleep-wake rhythm disorder (N24SWD) exhibit a sleep pattern that is asynchronous with the external light-dark cycle, typically involving a cycling, relapsing-remitting pattern of sleep disturbances, including nighttime insomnia and daytime sleepiness. Here, we report the case of a patient with N24SWD comorbid with major depressive disorder, who was successfu...

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ژورنال

عنوان ژورنال: Psychiatry and Clinical Neurosciences

سال: 1997

ISSN: 1323-1316,1440-1819

DOI: 10.1111/j.1440-1819.1997.tb02372.x