A short-term divergent selection for resistance to Teladorsagia circumcincta in Romanov sheep using natural or artificial challenge
نویسندگان
چکیده
منابع مشابه
Selection and characterisation of monepantel resistance in Teladorsagia circumcincta isolates
Monepantel (MPTL) is one of two new anthelmintic compounds introduced onto the sheep market to control gastro-intestinal nematodes. Resistance to this compound is rare but has been reported. In order to preserve the efficacy of this and other anthelmintics, it is essential to understand both (a) the mechanisms involved in the selection of resistance and (b) how the parasites evolve to deal with...
متن کاملShort Communication: Some Observations on the Role of Bradykinin in Immunity to Teladorsagia circumcincta in Sheep
Bradykinin is a physiologically active peptide involved in vasodilation and smooth muscle contraction and is previously shown to be increased in gastrointestinal mucus during nematode challenge in sheep. Here, it is shown that bradykinin in the abomasum is positively correlated with both mast cells and globule leukocytes in the abomasum, and that all three of these parameters are negatively ass...
متن کاملLocal cytokine transcription in naïve and previously infected sheep and lambs following challenge with Teladorsagia circumcincta
BACKGROUND The abomasal helminth Teladorsagia circumcincta is one of the most economically important parasites affecting sheep in temperate regions. Infection is particularly detrimental to lambs, in which it can cause pronounced morbidity and severe production losses. Due to the spreading resistance of this parasite to all classes of anthelmintic drugs, teladorsagiosis is having an increasingl...
متن کاملVariable exon usage of differentially-expressed genes associated with resistance of sheep to Teladorsagia circumcincta
The resistance and susceptibility of sheep to the common abomasal nematode parasite, Teladorsagia circumcincta is strongly associated with the differential polarization of the immune response. Resistant animals control larval colonization by the production of a protective antibody response regulated by Th2 T cells. Susceptible sheep respond to infection by developing an inflammatory Th1/Th17 re...
متن کاملGenetic basis of benzimidazole resistance in Teladorsagia circumcincta in Ireland
Resistance to benzimidazole (BZ) anthelmintics is common in ovine nematodes of economic importance. Single nucleotide polymorphisms (SNP) at three positions in the isotype 1 β- tubulin gene have been associated with BZ resistance and molecular tests for the detection of BZ resistance have been developed. In order to determine if such tests are practicable in Ireland the polymorphisms associated...
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ژورنال
عنوان ژورنال: Genetics Selection Evolution
سال: 2004
ISSN: 1297-9686
DOI: 10.1186/1297-9686-36-2-217