A sequence-specific threading tetra-intercalator with an extremely slow dissociation rate constant
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چکیده
منابع مشابه
A Sequence-Specific Threading Tetraintercalator with an Extremely Slow Dissociation Rate Constant
A long-lived and sequence-specific ligand-DNA complex would make possible the modulation of biological processes for extended periods. For this purpose, we are investigating a polyintercalation approach to DNA recognition in which flexible chains of aromatic units thread back and forth repeatedly through the double helix. Here we describe the DNA-binding behaviour of a threading tetra-intercala...
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ژورنال
عنوان ژورنال: Nature Chemistry
سال: 2011
ISSN: 1755-4330,1755-4349
DOI: 10.1038/nchem.1151