A seeding based cellular assay of tauopathy
نویسندگان
چکیده
منابع مشابه
Proteopathic tau seeding predicts tauopathy in vivo.
Transcellular propagation of protein aggregates, or proteopathic seeds, may drive the progression of neurodegenerative diseases in a prion-like manner. In tauopathies such as Alzheimer's disease, this model predicts that tau seeds propagate pathology through the brain via cell-cell transfer in neural networks. The critical role of tau seeding activity is untested, however. It is unknown whether...
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ژورنال
عنوان ژورنال: Molecular Neurodegeneration
سال: 2016
ISSN: 1750-1326
DOI: 10.1186/s13024-016-0100-9