A scalable device-less biomaterial approach for subcutaneous islet transplantation

The subcutaneous space has been shown to be a suitable site for islet transplantation, however an abundance of islets is required achieve normoglycemia, often requiring multiple donors. loss due the hypoxic conditions experience during revascularization, resulting in apoptosis. Therefore, reduce therapeutic dosage pre-vascularization pursued. In this study, we highlight biomaterial-based approach using methacrylic acid copolymer coating generate robust pre-vascularized cavity transplantation. We also devised simple, but not-trivial, procedure filling with suspension collagen. show that can support marginal mass rapidly return streptozotocin-induced diabetic SCID/bg mice normoglycemia. Furthermore, immunocompetent Sprague Daley rats remained normoglycemia up 70 days until they experienced graft destabilization as outgrew their implants. This work highlights acid-based biomaterials strategy scalable and doesn't require exogenous cells or growth factors.