A salivary vasodilator in the blood-sucking bug, Rhodnius prolixus
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چکیده
منابع مشابه
Exploring the sialome of the blood-sucking bug Rhodnius prolixus.
Rhodnius prolixus is a Hemiptera that feeds exclusively on vertebrate blood in all life stages. Its salivary glands produce potent pharmacological substances that counteract host hemostasis, including anti-clotting, anti-platelet, and vasodilatory substances. To obtain a further insight into the salivary biochemical and pharmacological complexity of this insect, a cDNA library was randomly sequ...
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The salivary glands of the blood-sucking bug Rhodnius prolixus are formed by a single layer of binucleated epithelial cells surrounded by a double layer of transversely oriented smooth muscle cells. The epithelial cells are rich in rough endoplasmic reticulum and mitochondria and have abundant microvillar projections towards the gland lumen. This cell layer surrounds a relatively large cavity w...
متن کاملPurification and characterization of prolixin S (nitrophorin 2), the salivary anticoagulant of the blood-sucking bug Rhodnius prolixus.
The salivary anticoagulant of the blood-sucking bug Rhodnius prolixus was purified to homogeneity using a protocol consisting of weak cation-exchange, DEAE, hydrophobic-interaction and octadecyl reverse-phase chromatography, yielding a protein with the same N-terminal sequence as nitrophorin 2, one of the four NO haem protein carriers present in the salivary glands of Rhodnius with a molecular ...
متن کاملAn unusual myosuppressin from the blood-feeding bug Rhodnius prolixus.
The myosuppressin (MS) gene was cloned from a central nervous system (CNS) cDNA library of the hematophagous insect Rhodnius prolixus and is predicted to contain two introns and three exons. The mRNA transcribed from the myosuppressin gene encodes an 88 amino acid prepropeptide, which results in a mature decapeptide after post-translational modification. When compared with the myosuppressins is...
متن کاملSalivary apyrase of Rhodnius prolixus
Joao J. F. SARKIS,* Jorge A. GUIMARAESt and Jose M. C. RIBEIRO$ *Department of Biochemistry, Federal University of Rio Grande do Sul, Instituto de Biosciencias, 90.000 Porto Alegre, RS, Brazil, tDepartment of Biochemistry, Federal University of Rio de Janeiro, Centro de Ciencias da Saude, Bloco H, 21.910 Rio de Janeiro, RJ, Brazil, and $Department of Tropical Public Health, Harvard School of Pu...
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ژورنال
عنوان ژورنال: British Journal of Pharmacology
سال: 1990
ISSN: 0007-1188
DOI: 10.1111/j.1476-5381.1990.tb14183.x