A role for synaptic zinc in ProSAP/Shank PSD scaffold malformation in autism spectrum disorders

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A Role for Synaptic Zinc in ProSAP/Shank PSD Scaffold Malformation in Autism Spectrum Disorders

The establishment and maintenance of synaptic contacts as well as synaptic plasticity are crucial factors for normal brain function. The functional properties of a synapse are largely dependent on the molecular setup of synaptic proteins. Multidomain proteins of the ProSAP/Shank family act as major organizing scaffolding elements of the postsynaptic density (PSD). Interestingly, ProSAP/Shank pr...

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ژورنال

عنوان ژورنال: Developmental Neurobiology

سال: 2013

ISSN: 1932-8451,1932-846X

DOI: 10.1002/dneu.22089