منابع مشابه
A Rhythmic Ror
The circadian clock mechanism in mammals involves two interlocking transcriptional feedback loops. Rev-erb alpha, through its role as a transcriptional repressor, was thought to be the primary determinant of the feedback loop that regulates Bmal1 transcription. Results reported by Sato et al. in this issue of Neuron now show that the transactivator Rora acts coordinately with Rev-erb alpha and ...
متن کاملPharmacologic Inhibition of ROR
IL-17–producing CD4 + Th17 cells, CD8 + Tc17 cells, and gd T cells play critical roles in the pathogenesis of autoimmune psoriasis. RORgt is required for the differentiation of Th17 cells and expression of IL-17. In this article, we describe a novel, potent, and selective RORgt inverse agonist (TMP778), and its inactive diastereomer (TMP776). This chemistry, for the first time to our knowledge,...
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All signaling pathways have their complexities , but Wnt signaling may be more complex than most. There are 19 different Wnt ligands in mammals that bind to multiple types of receptors, some of which activate a canonical pathway that stabilizes the tran-scriptional coactivator -catenin, and some of which signal via noncanonical, -catenin– independent pathways. Roarty et al. begin to unpick th...
متن کاملCloning and expression analysis of two ROR-γ homologues (ROR-γa1 and ROR-γa2) in rainbow trout Oncorhynchus mykiss.
This paper describes the cloning and characterisation of two retinoid-related orphan receptor (ROR)-γ homologues (ROR-γa1 and -γa2) in rainbow trout (Oncorhynchus mykiss). The coding region predicted for both homologues consists of 1410 base pairs (bp), which translate into two 469 amino acid (aa) proteins. The trout ROR-γs revealed a high conservation of both DNA- and ligand-binding domains (f...
متن کاملROR: Rejection of Outliers by Rotations
ÐWe address the problem of rejecting false matches of points between two perspective views. The two views are taken from two arbitrary, unknown positions and orientations. Even the best algorithms for image matching make some mistakes and output some false matches. We present an algorithm for identification of the false matches between the views. The algorithm exploits the possibility of rotati...
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ژورنال
عنوان ژورنال: Neuron
سال: 2004
ISSN: 0896-6273
DOI: 10.1016/j.neuron.2004.08.009