A revised airway epithelial hierarchy includes CFTR-expressing ionocytes
نویسندگان
چکیده
منابع مشابه
Junctional abnormalities in human airway epithelial cells expressing F508del CFTR.
Cystic fibrosis (CF) has a profound impact on airway physiology. Accumulating evidence suggests that intercellular junctions are impaired in CF. We examined changes to CF transmembrane conductance regulator (CFTR) function, tight junctions, and gap junctions in NuLi-1 (CFTR(wt/wt)) and CuFi-5 (CFTR(ΔF508/ΔF508)) cells. Cells were studied at air-liquid interface (ALI) and compared with primary h...
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The functional expression of the epithelial sodium channel (ENaC) appears elevated in cystic fibrosis (CF) airway epithelia, but the mechanism by which this occurs is not clear. We tested the hypothesis that the cystic fibrosis transmembrane conductance regulator (CFTR) alters the trafficking of endogenously expressed human ENaC in the CFBE41o⁻ model of CF bronchial epithelia. Functional expres...
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We developed a helper-dependent adenoviral vector for cystic fibrosis lung gene therapy. The vector expresses cystic fibrosis transmembrane conductance regulator (Cftr) using control elements from cytokeratin 18. The vector expressed properly localized CFTR in cultured cells and in the airway epithelia of mice. Cftr RNA and protein were present in whole lung and bronchioles, respectively, for 2...
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We show that, for an arbitrary function h(n) and each recursive function ‘(n), that are separated by a nondeterministically fully space constructible g(n), such that h(n)∈0(g(n)) but ‘(n) ∈ 0(g(n)), there exists a unary language L in NSPACE(h(n)) that is not contained in NSPACE(‘(n)). The same holds for the deterministic case. The main contribution to the well-known Space Hierarchy Theorem is t...
متن کاملCFTR is a modulator of airway inflammation.
ALTHOUGH IT HAS BEEN 17 YEARS since the identification of the cystic fibrosis transmembrane ion receptor (CFTR) gene and protein, it remains enigmatic how abnormalities in CFTR can cause chronic and persistent pulmonary infection and inflammation that lead to bronchiectasis and end-stage lung disease (9). Because CFTR regulates transepithelial chloride and sodium conductance, the most prominent...
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ژورنال
عنوان ژورنال: Nature
سال: 2018
ISSN: 0028-0836,1476-4687
DOI: 10.1038/s41586-018-0393-7