A review on orally disintegrating films (ODFs) made from natural polymers such as pullulan, maltodextrin, starch, and others

In recent years, orally disintegrating films (ODFs) have been studied as alternative ways for drug administration. They can easily be applied into the mouth and quickly disintegrate, releasing with no need of water ingestion enabling absorption through oral mucosa. The ODFs matrices are typically composed hydrophilic polymers, in which natural polymers highlighted since they extracted from sources, non-toxic, biocompatible, biodegradable, favorable properties this application. Besides that, such polysaccharides proteins either alone or blended other synthetic, semi-synthetic, to achieve better mechanical mucoadhesive fast disintegration. review, we analyzed developed using blends involving maltodextrin, pullulan, starch, gelatin, collagen, alginate, chitosan, pectin, others, overview publications discuss how influence properties.