A REVIEW ON NANO/MICROPARTICLES FORMULATION OF VACCINE DELIVERY FOR UNIVERSAL INFLUENZA

Worldwide, influenza affects millions of individuals and has the potential to cause serious illness or even death. The most effective approach prophylaxis is vaccination, but due strain viral mutation changes, seasonal vaccine frequently limited efficiency needs be administered annually. Although they have been employed clinically, more conserved universal antigens like M2 ectodomain (M2e) hemagglutinin stalk region (HA stalk) poor antigenicity. Universal created employing nano/microparticles as carriers boost their Indicators immunity protection against demonstrated in mouse, pig, ferret, chicken models using polymers, liposomes, metal, protein-based particles. This review focuses on physiochemical characteristics, production, characterization, biologic responses vivo formulations vaccines made from these materials. assessment concludes with future perspectives for carrier systems other factors take into account within perspective landscape administration vaccine. KEYWORDS: Influenza; Polymeric Nanoparticles; Liposomes; Gold Protein Nanoparticles