A Review on Gastro-Retentive Floating Microspheres

Formulation, optimization and evaluation of gastro-retentive floating microspheres of norfloxacin

The objective of the present study was to develop floating microsphere of norfloxacin in order to achieve an extended retention in the upper GIT which may enhance the absorption and improve the bioavailability. The microspheres were prepared by solvent evaporation method using different ratio of hydroxyl propyl methyl cellulose (HPMC K4M, HPMC K15M) and ethyl cellulose with drug in the mixture ...

Formulation Development and in Vitro Evaluation of Gastro Retentive Floating Microspheres of Verapamil Hydrocloride

Floating drug delivery system is one of the novel drug delivery system. Floating drug delivery system have a bulk density less than gastric fluids and thus it remains buoyant in the stomach without affecting gastric emptying rate for a prolonged period of time. Verapamil HCL is calcium channel blocker drug with short elimination half-life 2.8-7.4 hours Floating microspheres of Verapamil HCL wer...

Development of Gastro Retentive Floating Matrix Tablets of Diltiazem Hydrochloride

Cervicofacial hemangiomas treated from January 2001 to December 2009 was clinically evaluated. This retrospective clinical study consisted of 42 females and 20 males with the age ranged from 20 days to 55 years. The lesions were present with-in first month in 45 patients (72.6%). Two patterns of tumor growth were evident: focal and diffuse. There were 59 focal hemangiomas (80.8%) and 14 diffuse...

gastro retentive drug delivery systems: a review

gastric emptying is a complex and extremely variable process. this causes the unpredictability of the bioavailability of drug delivery systems. gastro retentive drug delivery systems (grdds)s have received significant interest in the past decades as they can overcome the limitation of conventional oral controlled release drug delivery systems related to fast gastric emptying time. an optimum gr...

Gastro-retentive Drug Delivery System