A Review on Anthracycline Induced Cardiotoxicity- A Mechanism-based Approach

Doxorubicin has become one of the most effective chemotherapeutic agents, but its use was complicated by development heart failure. Proposed mechanisms for antitumor effects included intercalation into DNA that caused prevention micro molecule synthesis, cross-linkage and binding, damage due to topoisomerase 2b suppression, reactive oxygen species production, induction apoptosis. Several drugs such as ACE inhibitors or angiotensin receptor blockers, beta-blockers CHF therapy are used treatment processes. The present brief review literature, focuses on literature based mechanism anthracycline-induced cardiotoxicity.