A review of estrogen receptor α gene (ESR1) polymorphisms, mood, and cognition
نویسندگان
چکیده
منابع مشابه
Role of Estrogen, Estrogen Receptor-α and ESR1 Polymorphisms in SLE
The etiology of SLE is not clearly understood but strong genetic predisposition has been recognized. Environmental and hormonal factors are known to contribute towards the expression of the disease. Among the above risk factors, female gender is considered to be of greatest significance. Thus estrogens and their receptors have been proposed as obvious candidates to explain this sexual dimorphis...
متن کاملAssociation study of the estrogen receptor alpha gene (ESR1) and childhood-onset mood disorders.
Depressive disorders are heterogeneous psychiatric disorders involving deficits in cognitive, psychomotor, and emotional processing. Depressive disorders have a significant genetic component, with severe, recurrent and early-onset forms demonstrating elevated heritability. In this study we genotyped eleven single nucleotide polymorphisms (SNPs) spanning the estrogen receptor alpha gene (ESR1) i...
متن کاملImpact of estrogen receptor α gene and oxytocin receptor gene polymorphisms on female sexuality
Over the past decades, research attention has increasingly been paid to the neurobiological component of sexual behavior. The aim of the present study was to investigate the correlation of estrogen receptor α (ERA) gene polymorphism (rs2234693-PvuII) (T→C substitution) and oxytocin receptor gene polymorphism (rs53576) (G→A substitution) with sexuality parameters of young, healthy women. One hun...
متن کاملGenetic polymorphisms in the estrogen receptor - α Gene codon 325(CCC}CCG) and risk of breast cancer among Iranian women: a case control study
Abstract Background: The Iranian breast cancer patients are relatively younger than their Western counterparts. Evidence suggests that alterations in estrogen signaling pathways , including estrogen receptor-α (ER- α ), occur during breast cancer development in Caucasians. Epidemiologic studies have revealed that age-incidence patterns of breast cancer in Asians differ from those in Cauca...
متن کاملEstrogen Receptor Alpha (ESR1) Gene Polymorphisms in Pre-eclamptic Saudi Patients
OBJECTIVES Pre-eclampsia causes maternal mortality worldwide. Estrogen receptor alpha (ESR1) gene polymorphisms were responsible for cardiovascular diseases. This case control study was conducted to investigate whether 2 polymorphic genes of ESR1 are associated with pre-eclampsia among Saudi women in Madina city, Saudi Arabia. METHODS Blood samples from 97 pre-eclamptic and 94 healthy pregnan...
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ژورنال
عنوان ژورنال: Menopause
سال: 2010
ISSN: 1072-3714
DOI: 10.1097/gme.0b013e3181df4a19