A Recombinant Plasmodium vivax Apical Membrane Antigen-1 to Detect Human Infection in Iran
نویسندگان
چکیده
منابع مشابه
A Recombinant Plasmodium vivax Apical Membrane Antigen-1 to Detect Human Infection in Iran
In Iran, Plasmodium vivax is responsible for more than 80% of the infected cases of malaria per year. Control interventions for vivax malaria in humans rely mainly on developed diagnostic methods. Recombinant P. vivax apical membrane antigen-1 (rPvAMA-1) has been reported to achieve designing rapid, sensitive, and specific molecular diagnosis. This study aimed to perform isolation and expressio...
متن کاملAnalysis of Plasmodium vivax Apical Membrane Antigen-1 (PvAMA-1) Haplotypes among Iranian Isolates
Plasmodium vivax apical membrane antigen-1(PvAMA-1) is a surface protein with polymorphic sites. This study was aimed to analyze the polymorphic amino acid residues at PvAMA-1 in different infected age groups. 92 blood samples were collected from south and southeast of Iran. The DNA coding for the domain I (DI), DII, and partial DIII of this antigen was amplified by Nested-PCR, and sequenced. N...
متن کاملApical membrane antigen-1 (AMA-1) gene sequences of re-emerging Plasmodium vivax in South Korea.
Plasmodium vivax malaria re-emerged in South Korea in 1993, and epidemics continue since then. We examined genetic variation in the region encompassing the apical membrane antigen-1 (PvAMA-1) of the parasites by DNA sequencing of the 22 re-emerging P. vivax isolates. The genotype of the PvAMA-1, which was based on sequence data previously reported for the polymorphic regions, showed that two ha...
متن کاملsequence analysis of different domains of plasmodium vivax apical membrane antigen (pvama-1 gene) locus in iran
background: plasmodium vivax is responsible for approximately 80 million malaria cases in the world. apical membrane antigen1 (ama-1) is a type i integral membrane protein present in all plasmodium species. ama-1 interferes in critical steps of invasion of human hepatocytes by sporozoites and red blood cells by merozoites and is one of the most immunodominant antigens for eliciting a protect...
متن کاملSequence Analysis of Different Domains of Plasmodium vivax Apical Membrane Antigen (PvAMA-1 gene) Locus in Iran
BACKGROUND Plasmodium vivax is responsible for approximately 80 million malaria cases in the world. Apical membrane antigen1 (AMA-1) is a type I integral membrane protein present in all Plasmodium species. AMA-1 interferes in critical steps of invasion of human hepatocytes by sporozoites and red blood cells by merozoites and is one of the most immunodominant antigens for eliciting a protective ...
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ژورنال
عنوان ژورنال: The Korean Journal of Parasitology
سال: 2012
ISSN: 1738-0006
DOI: 10.3347/kjp.2012.50.1.15