A Recent Overview: In Situ Gel Smart Carriers for Ocular Drug Delivery

Delivery of the drug to ocular area is blocked by protective layers covering eyes; it has always been a major problem find effective bioavailability active in due short duration precorneal majority stay. Direct delivery systems combine as well oil, solution, and suspension, result, many are not able effectively treat eye diseases. Many works have done being overcome this one which use in-situ build polymeric systems. Ocular In-situ gelling new class that initially solution but quickly transformed into viscous gel when introduced or inserted an cavity where drugs released continuously. This sol-to-gel phase conversion depends on variety factors such changes pH, ion presence, temperature changes. Post-transplanting selects viscosity bio-adhesive properties, prolongs gel's stay also releases long continuous way unlike conventional drops ointments. review brief overview situ gels, various methods systems, different types polymers used their gel-based methods, testing gel.
 Keywords: gel, Polymers, triggered Mechanism, Evaluation parameters