A Rare Entity of Accelerated Chronic Lymphocytic Leukemia: A Report of Two Cases and Review of Literature

Background: Accelerated-chronic lymphocytic leukemia (A-CLL) is a rare disease entity as it represents less than 1% of all reported cases chronic lymphoid (CLL). Moreover, most likely an under diagnosed due to its rarity and the non-standardized practice lymph node biopsy in CLL. Purpose: The aims our work are establish diagnosis A-CLL study prognosis treatment this entity. Method: here, we report clinical presentation follow up two A-CLL. Results: Distinguishing Richter transformation (RT) from important may result major change management. intermediate between CLL RT. mainly poor predominance prognostic markers including increasing number p53-positive cases. Conclusion: To date, no prospective has been led define best for shorter survival when compared typical implies need more aggressive treatment.