A Rare Case of Refractory Catastrophic Antiphospholipid Syndrome Successfully Treated With Rituximab and Plasma Exchange

A small subset of patients with antiphospholipid syndrome (APS) may develop widespread thrombotic disease organ damage, referred to as catastrophic APS (CAPS) that is associated a high mortality. Medical therapy typically involves combination anticoagulation, systemic glucocorticoids, plasmapheresis, and intravenous immune globulin (IVIG). There currently no consensus for the management refractory cases CAPS. However, monoclonal antibodies such rituximab eculizumab have shown some benefits. Herein, we present 29-year-old female previous pulmonary embolism who presented necrotic left toes was eventually diagnosed CAPS, successfully treated Plasmapheresis Rituximab. With this case report, hope encourage usage Rituximab in CAPS