A protein folding intermediate pulls its weight

نویسندگان

چکیده

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Implicit prosody pulls its weight: Recovery from garden path sentences

Classic reduced relative clause garden path sentences (e.g., The horse raced past the barn fell) are notoriously difficult to comprehend, even after repeated exposure [1, 2]. We present a silent eye tracking experiment showing that increasing the weight of the matrix verb phrase with a particle or an adverbial facilitates recovery from misanalysis, as in The horse raced past the barn fell (down...

متن کامل

Snapshots of a protein folding intermediate.

We have investigated the folding dynamics of Thermus thermophilus cytochrome c(552) by time-resolved fluorescence energy transfer between the heme and each of seven site-specific fluorescent probes. We have found both an equilibrium unfolding intermediate and a distinct refolding intermediate from kinetics studies. Depending on the protein region monitored, we observed either two-state or three...

متن کامل

Kinetics of chain motions within a protein-folding intermediate.

Small proteins can fold remarkably rapidly, even in μs. What limits their rate of folding? The Engrailed homeodomain is a particularly well-characterized example, which folds ultrafast via an intermediate, I, of solved structure. It is a puzzle that the helix2-turn-helix3 motif of the 3-helix bundle forms in approximately 2 μs, but the final docking of preformed helix1 in I requires approximate...

متن کامل

Detection of residue contacts in a protein folding intermediate.

Protein folding can be described in terms of the development of specific contacts between residues as a highly disordered polypeptide chain converts into the native state. Here we describe an NMR based strategy designed to detect such contacts by observation of nuclear Overhauser effects (NOEs). Experiments with alpha-lactalbumin reveal the existence of extensive NOEs between aromatic and aliph...

متن کامل

Protein translocation pulls the plug

Protein translocation pulls the plug embrane-bound compartments present an immediate problem: proteins need to get into and across those membranes. Now, we have the first picture of how that process works, thanks to the structure determined and colleagues. They find that a single SecY complex from Methanococcus jannaschii forms an hourglass-shaped pore with a basal plug that probably swings out...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: Journal of Biological Chemistry

سال: 2020

ISSN: 0021-9258

DOI: 10.1074/jbc.h120.015166