A preliminary neutron diffraction study of rasburicase, a recombinant urate oxidase enzyme, complexed with 8-azaxanthin

Effects of Recombinant Urate Oxidase (Rasburicase) and Allopurinol for Prophylaxis and Treatment of Hyperuricemia in Patients with Leukemia and Lymphoma

Background: Efficacy of rasburicase in pediatric patients with leukemia and lymphoma is proved. This study aims toweigh efficacy and safety of rasburicase versus more conventional therapy, allopurinol, and to compare their safetyand properties in tumor lysis syndrome (TLS) of leukemia and lymphoma patients.Materials and Methods: The study was done with a retrospective cohort design. Patients we...

Urate oxidase (rasburicase) for treatment of severe tophaceous gout.

Gout is a clinical disorder caused by deposition of urate crystals in a joint leading to acute inflammatory response with acute pain. In severe and longstanding gout, the crystals accumulate in soft tissues such as cartilage, subcutaneous tissue or even veins leading to the development of tophi responsible for very large deposit formations and disability. Most cases of gout present with the sud...

effects of recombinant urate oxidase (rasburicase) and allopurinol for prophylaxis and treatment of hyperuricemia in patients with leukemia and lymphoma

background: efficacy of rasburicase in pediatric patients with leukemia and lymphoma is proved. this study aims toweigh efficacy and safety of rasburicase versus more conventional therapy, allopurinol, and to compare their safetyand properties in tumor lysis syndrome (tls) of leukemia and lymphoma patients.materials and methods: the study was done with a retrospective cohort design. patients we...

Purification, crystallization and preliminary X-ray diffraction study of a recombinant cytokinin oxidase from Zea mays.

Cytokinins are hormones that are involved in plant growth and development. They are irreversibly degraded by cytokinin oxidases/dehydrogenases, flavoenzymes which contain a covalently bound flavine adenine dinucleotide (FAD) cofactor. Cytokinin oxidase from Zea mays (ZmCKO1) was overexpressed in the yeast Yarrowia lipolytica, purified (molecular weight 69 kDa) and crystallized using the hanging...

optimization of bacterial urate oxidase enzyme activity