A Powerful Weapon

Incretin-based therapy: a powerful and promising weapon in the treatment of type 2 diabetes mellitus

Type 2 diabetes mellitus (T2DM) is a progressive multisystemic disease that increases significantly cardiovascular morbidity and mortality. It is associated with obesity, insulin resistance, beta-cell dysfunction, and hyperglucagonemia, the combination of which typically leads to hyperglycemia. Incretin-based treatment modalities, and in particular glucagon-like peptide 1 (GLP-1) receptor agoni...

Inhibition of PCSK9: a powerful weapon for achieving ideal LDL cholesterol levels.

P lasma LDL cholesterol level is a major determinant of cardiovascular disease (CVD) risk. The striking results of the early large-scale statin trials showed that LDL levels can be reduced by 30–40% with comparable percentage reductions in CVD risk. More recent trials show that there is progressively greater relative risk reduction as the on-treatment level of LDL drops. In the JUPITER trial (1...

Is tenofovir disoproxil fumarate an all-powerful weapon in the treatment of chronic hepatitis B?

Copyright © 2015 The Korean Association of Internal Medicine This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/ by-nc/3.0/) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited. pISSN 1226-3303 eISSN 2005-664...

A mighty weapon: steam sterilization.

Another weapon against amyloid.

A lzheimer’s disease (AD) is one of those conditions that, like cancer in earlier generations, inspires particular terror among the general public. Therapeutic advances have lagged behind insights into genetics and pathophysiology, and although -amyloid (A ), the product of amyloid precursor protein (APP) cleavage, remains the leading suspect among proposed pathogenic factors, its causal role i...