A portable ventilator with integrated physiologic monitoring for hyperpolarized 129Xe MRI in rodents
نویسندگان
چکیده
منابع مشابه
Fast dynamic ventilation MRI of hyperpolarized 129Xe using spiral imaging
PURPOSE To develop and optimize a rapid dynamic hyperpolarized 129 Xe ventilation (DXeV) MRI protocol and investigate the feasibility of capturing pulmonary signal-time curves in human lungs. THEORY AND METHODS Spiral k-space trajectories were designed with the number of interleaves Nint = 1, 2, 4, and 8 corresponding to voxel sizes of 8 mm, 5 mm, 4 mm, and 2.5 mm, respectively, for field of...
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Introduction Hyperpolarized (HP) gas MRI in small animals is challenging and generally requires a dedicated ventilator system. Moreover, the use of expensive rare isotopes such as He and Xe make it desirable to minimize cost by recycling these gases after they have been used for imaging. We present a constantvolume ventilator that offers precise control of gas delivery, permits highresolution i...
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S. Patz, I. Muradian, M. I. Hrovat, J. P. Butler, G. P. Topulos, S. Ketel, I. C. Ruset, S. Covrig, F. W. Hersman Radiology, Brigham and Women's Hospital, Boston, MA, United States, Physics, University of New Hampshire, Durham, NH, United States, Mirtech, Inc., Brockton, MA, United States, Physiology, Harvard School of Public Health, Boston, MA, United States, Anesthesiology, Brigham and Women's...
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High-sensitivity nuclear magnetic resonance (NMR) of gaseous atoms realized by using a hyperpolarization technique is an attractive research tool used in a wide range of areas, such as physics, chemistry, material science and biomedical imaging. One of the most promising applications of this technology is the use as a noninvasive diagnostic tool for pulmonary diseases, where hyperpolarized (HP)...
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Hyperpolarized (hp) (83)Kr is a promising MRI contrast agent for the diagnosis of pulmonary diseases affecting the surface of the respiratory zone. However, the distinct physical properties of (83)Kr that enable unique MRI contrast also complicate the production of hp (83)Kr. This work presents a previously unexplored approach in the generation of hp (83)Kr that can likewise be used for the pro...
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ژورنال
عنوان ژورنال: Journal of Magnetic Resonance
سال: 2018
ISSN: 1090-7807
DOI: 10.1016/j.jmr.2018.07.017