A porcine reproductive and respiratory syndrome virus (PRRSV) vaccine candidate based on the fusion protein of PRRSV glycoprotein 5 and the Toll-like Receptor-5 agonist Salmonella Typhimurium FljB
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چکیده
منابع مشابه
A porcine reproductive and respiratory syndrome virus (PRRSV) vaccine candidate based on the fusion protein of PRRSV glycoprotein 5 and the Toll-like Receptor-5 agonist Salmonella Typhimurium FljB
BACKGROUND Porcine reproductive and respiratory syndrome (PRRS) is characterized by severe reproductive failure and severe pneumonia in neonatal pigs and is caused by PRRS virus (PRRSV). Glycoprotein 5 (GP5) from PRRSV is a key inducer of neutralizing antibodies. Flagellin, a toll-like receptor 5 (TLR-5) agonist, is an effective inducer of innate immune responses. This study presents a novel PR...
متن کاملSynergism between porcine reproductive and respiratory syndrome virus (PRRSV) and Salmonella choleraesuis in swine.
Porcine reproductive and respiratory syndrome virus (PRRSV) and Salmonella choleraesuis are two leading causes of economic loss in the swine industry. While respiratory disease is common in both S. choleraesuis and PRRSV infections, the factors that contribute to its development remain largely undefined. We investigated the interaction of PRRSV, S. choleraesuis, and stress in 5-week-old swine. ...
متن کاملSynergism between Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) and Salmonella choleraesuis
Robert W. Wills, DVM PhD, Veterinary Diagnostic Center, University of Nebraska Paula J. Fedorka-Cray, PhD, USDA-ARSNational Animal Disease Center, Ames, IA K.-J. Yoon, DVM PhD, Veterinary Diagnostic Laboratory, Iowa State University Jeffery T. Gray, PhD, Microbiology Department, University of Osteopathic Medicine and Health Sciences, Des Moines, IA Tom Stabel, PhD, USDA-ARS-National Animal Dise...
متن کاملFunctional Characterization of Phosphorylation of the Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) Nucleocapsid Protein
The nucleocapsid (N) protein of porcine reproductive and respiratory syndrome virus (PRRSV) is a basic multifunctional protein which has been reported to be a serine phosphoprotein with yet-identified functions. As a first step towards understanding the general role of N protein phosphorylation during virus replication, the non-phosphorylated mutant N gene was constructed by mutating all serine...
متن کاملNonstructural protein 11 (nsp11) of porcine reproductive and respiratory syndrome virus (PRRSV) promotes PRRSV infection in MARC-145 cells
BACKGROUND Porcine reproductive and respiratory syndrome virus (PRRSV) induces one of most important devastating disease of swine worldwide, and the current methods poorly control it. Previous studies have indicated that the nonstructural protein 11 (nsp11) of PRRSV may be an important protein for the immune escape of PRRSV. RESULTS Here, we firstly explored the effect of over-expression of n...
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ژورنال
عنوان ژورنال: BMC Veterinary Research
سال: 2015
ISSN: 1746-6148
DOI: 10.1186/s12917-015-0439-0