A patient with Gaucher disease and plasma cell dyscrasia: bidirectional impact
نویسندگان
چکیده
منابع مشابه
A Case of IgG2 Heavy Chain Deposition Disease in a Patient with Kappa Positive Plasma Cell Dyscrasia
IgG2 heavy chain deposition disease (HCDD) is extremely rare. To date, only 4 cases have been reported in medical literature. To our knowledge, we report the first case of IgG2 HCDD accompanied by kappa plasma cell dyscrasia.
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Immunoglobulin-secreting cells (ISC) in peripheral blood mononuclear cells (PBM) isolated from patients with plasma cell dyscrasia of various stages were studied using reverse hemolytic plaque assay. Normal healthy individuals contained 35 +/- 16 ISC/10(5) PBM. Aleukemic or subleukemic patients with overt myeloma contained 825 +/- 713 ISC, whereas leukemic patients contained 12,675 +/- 2520 ISC...
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The clinical, hematologic, and immunoglobulin features of a new form of plasma cell dyscrasia (deleted H and L chain disease) are described. The clinical manifestations are periodic fever and weakness, lymphadenopathy, and hepatosplenomegaly. The hematologic abnormalities are anemia, leukopenia, lymphocytosis, thrombocytopenia, and increased plasma cells in lymph nodes and bone marrow. The prot...
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ژورنال
عنوان ژورنال: Hematology
سال: 2020
ISSN: 1520-4391,1520-4383
DOI: 10.1182/hematology.2020000123