A Pancreatic Polypeptide-Producing Pancreatic Tumor Causing WDHA Syndrome
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چکیده
منابع مشابه
A Pancreatic Polypeptide-Producing Pancreatic Tumor Causing WDHA Syndrome
We report the case of a 46-year-old female patient with WDHA (watery diarrhea/hypokalemia/achlorhydria) syndrome caused by a pancreatic polypeptide-producing tumor in the head of the pancreas. Whereas VIP and other pancreatic endocrine hormones were in the normal range, only serum levels of pancreatic polypeptide were elevated. Imaging studies identified a pancreatic tumor in the head of the gl...
متن کاملPancreatic polypeptide hyperplasia causing watery diarrhea syndrome: a case report.
Neuroendocrine tumours of the pancreas can secrete numerous peptides, leading to various recognizable clinical syndromes. The secretion of pancreatic polypeptide has been used as a marker for neuroendocrine tumours but is considered to be a biologically inert peptide. A 37-year-old woman had watery diarrhea syndrome from pancreatic polypeptide hyperplasia. Only 2 other reported cases in the lit...
متن کاملPancreatic Polypeptide
Pancreatic Polypeptide (PP) is a 36 amino acid peptide produced and secreted by PP cells (originally termed F cells) of the pancreas which are primarily located in the Islets of Langerhans. It is part of a family of peptides that also includes Peptide YY (PYY) and Neuropeptide Y (NPY). PP is rapidly released after a meal but remains elevated for 4-6 hours in humans with the Vagus nerve being th...
متن کاملPancreatic polypeptide.
Pancreatic polypeptide (PP) was discovered fortuitously during the purification of insulin from birds (Kimmel et al., 1968) and later from mammals (Chance et al., 1976). PP has since been extracted and purified from several mammalian species. It contains 36 amino-acid residues and is quite distinct from other known hormonal peptides (Lin and Chance, 1974). The amino-acid sequence of the peptide...
متن کاملPolypeptide Core of a Human Pancreatic Tumor Mucin Antigen1
This work describes the molecular properties of the polypeptide core of a human pancreatic mucin antigen isolated from a human pancreatic adenocarcinoma cell line, HPAF. Pancreatic tumor mucin was isolated by a combination of molecular sieve Chromatograph) and CsCI/4 M guanidine-HCI density gradient ultracentrifugation. Trifluoromethane sulfonic acid was used to remove carbohydrate units from p...
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ژورنال
عنوان ژورنال: Case Reports in Gastroenterology
سال: 2008
ISSN: 1662-0631
DOI: 10.1159/000142739