A Novel Mannose-binding Lectin-associated Serine Protease 1/3 Gene Variant
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چکیده
منابع مشابه
P 144: Sunflower Mannose binding Lectin-Associated Serine Protease Inhibitor-1 (SFMI-1) and -2: Significant Inhibitors of Mannose binding Lectin Pathway which Helps in Multiple Sclerosis Treatment
One of the important parts of innate immunity is complement system that occurs in three different ways; the classic, the alternative and the lectin pathway. The four pattern recognition molecules that have been identified till now are Mannose binding lectin (MBL), a component of lectin pathway, and three ficolins (ficolin1,-2 and -3) which compound to the carbohydrates of the cell surface. MBL ...
متن کاملp 144: sunflower mannose binding lectin-associated serine protease inhibitor-1 (sfmi-1) and -2: significant inhibitors of mannose binding lectin pathway which helps in multiple sclerosis treatment
one of the important parts of innate immunity is complement system that occurs in three different ways; the classic, the alternative and the lectin pathway. the four pattern recognition molecules that have been identified till now are mannose binding lectin (mbl), a component of lectin pathway, and three ficolins (ficolin1,-2 and -3) which compound to the carbohydrates of the cell surface. mbl ...
متن کاملA true autoactivating enzyme. Structural insight into mannose-binding lectin-associated serine protease-2 activations.
Few reports have described in detail a true autoactivation process, where no extrinsic cleavage factors are required to initiate the autoactivation of a zymogen. Herein, we provide structural and mechanistic insight into the autoactivation of a multidomain serine protease: mannose-binding lectin-associated serine protease-2 (MASP-2), the first enzymatic component in the lectin pathway of comple...
متن کاملLectin-Associated Serine Protease Complex of Ficolin and Mannose-Binding Cutting Edge: Complement-Activating
متن کامل
Functional estimation of mannose binding lectin associated serine protease (MBL-MASPs) in human serum.
BACKGROUND & OBJECTIVE Mannose binding lectin (MBL), a C-type or Ca(2+) dependent lectin, plays a major role in lectin pathway of complement activation. MBL deficiency/insufficiency is associated with susceptibility to many infections. It is important to know the association of functional lectin levels with disease condition. Therefore, we carried out this study to develop a simple assay to est...
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ژورنال
عنوان ژورنال: Scandinavian Journal of Immunology
سال: 2007
ISSN: 0300-9475,1365-3083
DOI: 10.1111/j.1365-3083.2007.01925.x