A Novel Chimeric Adenoassociated Virus 2/Human Bocavirus 1 Parvovirus Vector Efficiently Transduces Human Airway Epithelia
نویسندگان
چکیده
منابع مشابه
In vitro modeling of human bocavirus 1 infection of polarized primary human airway epithelia.
Human bocavirus 1 (HBoV1) is an emerging human-pathogenic respiratory virus. We characterized two important features of HBoV1 infection in polarized primary human airway epithelia (HAE). Apical HBoV1 infection of HAE at a low multiplicity of infection causes disruption of the tight junction barrier, loss of cilia, and epithelial cell hypertrophy, which are hallmarks of the airway epithelial dam...
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ژورنال
عنوان ژورنال: Molecular Therapy
سال: 2013
ISSN: 1525-0016
DOI: 10.1038/mt.2013.92