A Novel Assay for Detecting Fusion Pore Formation: Implications for the Fusion Mechanism
نویسندگان
چکیده
منابع مشابه
The exocytotic fusion pore
T hE fusion pore is the molecular structure that transiently connects the lumens of two membrane compartments during their fusion. The fusion of membrane compartments occurs in all cells because intracellular trafficking of vesicles in both endocytic and exocytic pathways and in consti-tutive exocytosis are ubiquitous cellular processes. In addition, many other cells including endocrine, exocri...
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The secretory process requires many different steps and stages. Vesicles must be formed and transported to the target membrane. They must be tethered or docked at the appropriate sites and must be prepared for fusion (priming). As the last step, a fusion pore is formed and the contents are released. Release of neurotransmitter is an extremely rapid event leading to rise times of the postsynapti...
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UNLABELLED NUT midline carcinoma (NMC) is an aggressive subtype of squamous cell carcinoma that typically harbors BRD4/3-NUT fusion oncoproteins that block differentiation and maintain tumor growth. In 20% of cases, NUT is fused to uncharacterized non-BRD gene(s). We established a new patient-derived NMC cell line (1221) and demonstrated that it harbors a novel NSD3-NUT fusion oncogene. We find...
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For paramyxoviruses, entry requires a receptor-binding protein (hemagglutinin-neuraminidase [HN], H, or G) and a fusion protein (F). Like other class I viral fusion proteins, F is expressed as a prefusion metastable protein that undergoes a refolding event to induce fusion. HN binding to its receptor triggers F refolding by an unknown mechanism. HN may serve as a clamp that stabilizes F in its ...
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ژورنال
عنوان ژورنال: Biochemistry
سال: 2013
ISSN: 0006-2960,1520-4995
DOI: 10.1021/bi401369j