A Notch updated

A Notch updated

Cell-cell signaling mediated by the Notch receptor is iteratively involved in numerous developmental contexts, and its dysregulation has been associated with inherited genetic disorders and cancers. The core components of the signaling pathway have been identified for some time, but the study of the modulation of the pathway in different cellular contexts has revealed many layers of regulation....

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A Notch Sweeter

Notch is a key signaling protein mediating cell-fate decisions during development. In this issue, Acar et al. (2008) describe a new gene called rumi that is required for Notch signaling in Drosophila. This gene encodes an O-glucosyltransferase that attaches glucose sugars to serine residues in the multiple EGF domains of the extracellular region of Notch. This modification by Rumi likely influe...

Kick it up a notch: Notch signaling and kidney fibrosis

Notch is a critical regulator of kidney development, but the pathway is mostly silenced once kidney maturation is achieved. Recent reports demonstrated increased expression of Notch receptors and ligands both in acute and chronic kidney injury. In vivo studies indicated that Notch activation might contribute to regeneration after acute kidney injury; on the other hand, sustained Notch expressio...

A Notch Affair

(Fortini and Artavanis-Tsakonas, 1994), or that activation Poulson first described Drosophila embryos that lacked brings about proteolytic cleavage of Notch, so that an Notch function in 1937 (Poulson, 1937), referring to them intracellular portion of Notch itself moves to the nucleus as “a kind of hopeless monster.” Half a century later it and collaborates with CSL to activate transcription (K...