A noninvasive assay for monitoring renal allograft status

Noninvasive monitoring of mouse renal allograft rejection using micro-CT

PURPOSE Acute renal graft rejection can only be definitively diagnosed by renal biopsy. However, biopsies carry a risk of renal transplant injury and loss. Micro-CT is widely used in preclinical studies of small animals. Here, we propose micro-CT could noninvasively monitor and evaluate renal location and function in a mouse kidney transplant model. METHODS Orthotopic kidney transplantation w...

microrna and renal allograft monitoring

MicroRNA and Renal Allograft Monitoring

Implication for health policy/practice/research/medical education: Renal allograft monitoring is a great challenge of transplantation medicine and different biomarkers have been proposed. MicroRNA is an appealing biomarker because we could trace it from different sources including biopsy samples urine and blood, particularly, miRNA signature of stable and impending to failure allograft in urin...

Noninvasive multianalyte diagnostic assay for monitoring bladder cancer recurrence

BACKGROUND The purpose of this study was to establish the clinical performance of a urine-based assay, called a multianalyte diagnostic readout, in monitoring for bladder cancer recurrence. METHODS This was a prospective, multicenter, single assessment observational study. The multianalyte diagnostic readout uses a combination of one protein and three DNA biomarkers. Urine samples from 733 pa...

Proteinuria as a Noninvasive Marker for Renal Allograft Histology and Failure: An Observational Cohort Study.

Proteinuria is routinely measured to assess renal allograft status, but the diagnostic and prognostic values of this measurement for renal transplant pathology and outcome remain unclear. We included 1518 renal allograft recipients in this prospective, observational cohort study. All renal allograft biopsy samples with concomitant data on 24-hour proteinuria were included in the analyses (n=227...