A non‐canonical function of Ezh2 preserves immune homeostasis
نویسندگان
چکیده
منابع مشابه
EZH2 phosphorylation by JAK3 mediates a switch to noncanonical function in natural killer/T-cell lymphoma.
The best-understood mechanism by which EZH2 exerts its oncogenic function is through polycomb repressive complex 2 (PRC2)-mediated gene repression, which requires its histone methyltransferase activity. However, small-molecule inhibitors of EZH2 that selectively target its enzymatic activity turn out to be potent only for lymphoma cells with EZH2-activating mutation. Intriguingly, recent discov...
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ژورنال
عنوان ژورنال: EMBO reports
سال: 2017
ISSN: 1469-221X,1469-3178
DOI: 10.15252/embr.201643237