A non-canonical Notch complex regulates adherens junctions and vascular barrier function
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چکیده
منابع مشابه
Adherens Junctions, Desmosomes and Tight Junctions in Epidermal Barrier Function
The skin is an indispensable barrier which protects the body from the uncontrolled loss of water and solutes as well as from chemical and physical assaults and the invasion of pathogens. In recent years several studies have suggested an important role of intercellular junctions for the barrier function of the epidermis. In this review we summarize our knowledge of the impact of adherens junctio...
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OBJECTIVE Endothelial cells provide a barrier between the blood and tissues, which is reduced during inflammation to allow selective passage of molecules and cells. Adherens junctions (AJ) play a central role in regulating this barrier. We aim to investigate the role of a distinctive 3-dimensional reticular network of AJ found in the endothelium. METHODS AND RESULTS In endothelial AJ, vascula...
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Unique intercellular junctional complexes between the central nervous system (CNS) microvascular endothelial cells and the choroid plexus epithelial cells form the endothelial blood-brain barrier (BBB) and the epithelial blood-cerebrospinal fluid barrier (BCSFB), respectively. These barriers inhibit paracellular diffusion, thereby protecting the CNS from fluctuations in the blood. Studies of br...
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Endothelial cells (ECs) form a tight barrier to prevent vascular leakage. Although several studies reported that vascular leakage is increased during hypoxic conditions, other studies describe a protective effect. This raises the question how hypoxia specifically regulates adherens junction integrity and thus endothelial barrier function. Here, we investigated how hypoxia and the hypoxia-mimeti...
متن کاملFlow mechanotransduction regulates traction forces, intercellular forces, and adherens junctions.
Endothelial cells respond to fluid shear stress through mechanotransduction responses that affect their cytoskeleton and cell-cell contacts. Here, endothelial cells were grown as monolayers on arrays of microposts and exposed to laminar or disturbed flow to examine the relationship among traction forces, intercellular forces, and cell-cell junctions. Cells under laminar flow had traction forces...
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ژورنال
عنوان ژورنال: Nature
سال: 2017
ISSN: 0028-0836,1476-4687
DOI: 10.1038/nature24998