منابع مشابه
NODding off AKI with Progranulin?
Inflammation is a common feature of murine models of AKI. The endogenous mechanisms which serve to limit inflammation and reduce the severity of AKI are poorly understood. Zhou et al identify progranulin as one such protective mediator. Deficiency of progranulin was associated with increased inflammation and increased injury in both ischemic and nephrotoxic models of AKI. Moreover, administrati...
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The hexosamine biosynthetic pathway (HBP) generates metabolites for protein N- and O-glycosylation. Wang et al. and Denzel et al. report a hitherto unknown link between the HBP and stress in the endoplasmic reticulum. These studies establish the HBP as a critical component of the cellular machinery of protein homeostasis.
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The accumulation of unfolded proteins in the lumen of the endoplasmic reticulum (ER) induces a coordinated adaptive program called the unfolded protein response (UPR). The UPR alleviates stress by upregulating protein folding and degradation pathways in the ER and inhibiting protein synthesis. With a basic conceptual framework for the UPR, including the identification of key mediators of the re...
متن کاملAcquaintance Time of a Graph
We define the following parameter of connected graphs. For a given graph G = (V,E) we place one agent in each vertex v ∈ V . Every pair of agents sharing a common edge are declared to be acquainted. In each round we choose some matching of G (not necessarily a maximal matching), and for each edge in the matching the agents on this edge swap places. After the swap, again, every pair of agents sh...
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ژورنال
عنوان ژورنال: Cell Death Discovery
سال: 2016
ISSN: 2058-7716
DOI: 10.1038/cddiscovery.2016.37