منابع مشابه
A New Twist on Brown Fat Metabolism
The transcriptional coactivator PGC-1alpha promotes mitochondrial biogenesis and thermogenic programs in brown adipose tissue. Pan et al. (2009) identify the transcription factor twist-1 as a negative feedback regulator of PGC-1alpha.
متن کاملTwist-1 Is a PPARδ-Inducible, Negative-Feedback Regulator of PGC-1α in Brown Fat Metabolism
Brown fat is specialized for energy expenditure, a process that is principally controlled by the transcriptional coactivator PGC-1alpha. Here, we describe a molecular network important for PGC-1alpha function and brown fat metabolism. We find that twist-1 is selectively expressed in adipose tissue, interacts with PGC-1alpha, and is recruited to the promoters of PGC-1alpha's target genes to supp...
متن کاملTurning on Brown Fat and Muscle Metabolism: Hedging Your Bets
Developmental genes are essential in the formation and function of adipose tissue and muscle. In this issue of Cell, Teperino et al. demonstrate that noncanonical hedgehog signaling increases glucose uptake into brown fat and muscle. Modulation of developmental pathways may serve as a potential target for new treatments of diabetes and other metabolic disorders.
متن کاملTranscriptional Activity of PGC-1α and NT-PGC-1α Is Differentially Regulated by Twist-1 in Brown Fat Metabolism
Brown fat expresses two PGC-1α isoforms (PGC-1α and NT-PGC-1α) and both play a central role in the regulation of cellular energy metabolism and adaptive thermogenesis by interacting with a wide range of transcription factors including PPARγ, PPARα, ERRα, and NRF1. PGC-1α consists of 797 amino acids, whereas alternative splicing of the PGC-1α gene produces a shorter protein called NT-PGC-1α (aa ...
متن کاملSimulation of a New Process Design to Fabricate a Rectangular Twist Waveguide Using Extrusion and a Twist Die
The aim of the present study is to determine the feasibility of making a rectangular twist waveguide used to rotate electromagnetic waves. For this purpose, the process of fabricating an aluminum rectangular twist waveguide was simulated by making use of finite element method and Deform software. The optimum length and angle of the twist die for manufacturing a twist waveguide with inner cross ...
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ژورنال
عنوان ژورنال: Cell
سال: 2009
ISSN: 0092-8674
DOI: 10.1016/j.cell.2009.03.029