A New Synthesis of Aldehydes and Aldehydes-dfrom Grignard Reagents
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چکیده
منابع مشابه
Enantioselective Addition of Grignard Reagents to Aldehydes
The addition of Grignard reagents to aldehydes in the presence of chiral aminoalcohols shows a moderate enantioselectivity. The study carried out with a series of ligands allows the correlation between the structural characteristics and their reactivity. Introduction The use of chiral aminoalcohol to lead asymmetrically nucleophilic additions of organometallics to carbonyl compounds is a field ...
متن کاملEvidence that Additions of Grignard Reagents to Aliphatic Aldehydes Do Not Involve Single-Electron-Transfer Processes.
Addition of allylmagnesium reagents to an aliphatic aldehyde bearing a radical clock gave only addition products and no evidence of ring-opened products that would suggest single-electron-transfer reactions. The analogous Barbier reaction also did not provide evidence for a single-electron-transfer mechanism in the addition step. Other Grignard reagents (methyl-, vinyl-, t-Bu-, and triphenylmet...
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Conjugate addition of organocopper reagents to ct,-ethylenic aldehydes is discussed. Use of cz,r3-ethylenic aminals is an— other approach to the same target, namely homologation of R-M to an aldehyde with three more carbon atoms. The c,-ethylenic aldehydes are easily prepared by carbocupration of c,13-acetylenic acetals. A new way to cz,t3-ethylenic ketones, mediated by organo copper reagents i...
متن کاملSnAP reagents for the one-step synthesis of medium-ring saturated N-heterocycles from aldehydes.
Interest in saturated N-heterocycles as scaffolds for the synthesis of bioactive molecules is increasing. Reliable and predictable synthetic methods for the preparation of these compounds, especially medium-sized rings, are limited. We describe the development of SnAP (Sn amino protocol) reagents for the transformation of aldehydes into seven-, eight- and nine-membered saturated N-heterocycles....
متن کاملInteraction of amines with ketone aldehydes and unsaturated aldehydes.
The optical changes occurring during the interaction of amines with ketone aldehydes or unsaturated aldehydes are accompanied by strong electron spin resonance signals, and can thus be explained as due to the transfer of one whole electron in the ground state.
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ژورنال
عنوان ژورنال: Bulletin of the Chemical Society of Japan
سال: 1982
ISSN: 0009-2673,1348-0634
DOI: 10.1246/bcsj.55.1663