A new stable GIP–Oxyntomodulin hybrid peptide improved bone strength both at the organ and tissue levels in genetically-inherited type 2 diabetes mellitus

A new stable GIP-Oxyntomodulin hybrid peptide improved bone strength both at the organ and tissue levels in genetically-inherited type 2 diabetes mellitus.

Obesity and type 2 diabetes mellitus (T2DM) progress worldwide with detrimental effects on several physiological systems including bone tissue mainly by affecting bone quality. Several gut hormones analogues have been proven potent in ameliorating bone quality. In the present study, we used the leptin receptor-deficient db/db mice as a model of obesity and severe T2DM to assess the extent of bo...

Exenatide Improves Bone Quality in a Murine Model of Genetically Inherited Type 2 Diabetes Mellitus

Type 2 diabetes mellitus (T2DM) is associated with skeletal complications, including an increased risk of fractures. Reduced blood supply and bone strength may contribute to this skeletal fragility. We hypothesized that long-term administration of Exenatide, a glucagon-like peptide-1 receptor agonist, would improve bone architecture and strength of T2DM mice by increasing blood flow to bone, th...

Serum Adiponectin and Vaspin levels in Abdominal Obesity and Type 2 Diabetes Mellitus

Abstract Objective: Adiponectin and vaspin are adipocyte-derived proteins and involved in the regulation of glucose metabolism and obesity related disorders. The mechanisms that adipokines might be linked to disturbance of glucose are unclear. Thus, this study investigated the levels of serum adiponectin and vaspin, blood lipid profiles, and abdominal obesity in type 2 diabetes (T2DM) patients...

The Relationship Between Type 2 Diabetes Mellitus and Osteoporosis in Elderly People: a Cross-sectional Study

Diabetes mellitus (DM) and osteoporosis are common diseases and their prevalence increases with age. Several investigations have indicated that type 1 DM has a significant relationship with bone loss, whereas in type 2 diabetes, this relationship is controversial. Therefore, this study was conducted to determine the relationship between osteoporosis and type 2 DM in elderly people. This populat...

Lifestyle and increased urinary Cadmium Levels in People with Type 2 Diabetes Mellitus: A Case Control Study in Tehran