A New Porcine Reproductive and Respiratory Syndrome Virus with N-Linked Glycosylation Site Deletion in GP5 44th Amino Acid from JXA1, NADC30-Like, and JM Triparental Recombination

Porcine reproductive and respiratory syndrome virus (PRRSV) is a significant pathogen causing substantial financial losses in the global swine industry. The prevention of PRRSV hampered due to frequent gene recombination among different strains PRRSV. In this study, new strain, PRRSV-HQ-2020, was identified from nursery piglets Yunnan Province, China, 2020. complete genome analysis revealed that PRRSV-HQ-2020 highly similar JXA1-like (lineage 8.7 PRRSV, isolated China 2008) 5′UTR, nsp1–9, nsp11 coding regions. Additionally, it has resemblance JM 3 Taiwan, 2010) nsp12-M region NADC30 1.8 North American nsp10, N, 3′UTR, suggesting natural event. Furthermore, analyses showed three interlineage events lineages 8.7, 1.8, 3. Notably, GP5 protein exhibited crucial mutation at position 44, leading deletion key glycosylation site. These findings provide direct evidence for occurrence PRRSV-2 Chinese herds, emergence unique genetic properties variants, providing theoretical basis developing better strategies.