A New Observation of Bone Marrow Involvement by Diffuse Large B-Cell Lymphoma Mimicking Myelofibrosis

Diffuse large B-cell lymphoma (DLBCL) is the most common non-Hodgkin lymphoma, characterized by high clinical and biological heterogeneity. Patients typically present with progressive lymphadenopathy, extranodal disease may also experience fever, night sweats unexplained weight loss. We report here case of a 16-year-old female osteoarticular pain, dizziness, dyspnea on exertion. Clinical examination showed no lymphadenopathy. Complete blood count (CBC) revealed pancytopenia marrow smears found to be hypocellular. Initial diagnosis favored secondary myelofibrosis. Diagnosis bone involvement DLBCL was retained histology immunohistochemistry which infiltration B lymphoid cells. The patient treated immunochemotherapy R-CHOP regimen. This highlights very rare atypical circumstance discovery myelofibrosis as an initial symptom. Prognosis value this presentation management difficulties are discussed.