A New 1D Ni (II) Coordination Polymer of s-Triazine Type Ligand and Thiocyanate as Linker via Unexpected Hydrolysis of 2,4-Bis(3,5-dimethyl-1H-pyrazol-1-yl)-6-methoxy-1,3,5-triazine

A new 1D Ni(II) coordination polymer was synthesized by the reaction of NiSO4·6H2O with 2,4-bis(3,5-dimethyl-1H-pyrazol-1-yl)-6-methoxy-1,3,5-triazine (BPT) and SCN− as a linker in an acidic medium heating under reflux conditions. Unusually, BPT ligand underwent acid-mediated hydrolysis losing one pyrazolyl arms afforded polymeric [Ni(MPT)(H2O)(SCN)2]n complex (MPT: 4-(3,5-dimethyl-1H-pyrazol-1-yl)-6-methoxy-1,3,5-triazin-2-ol. The center is coordinated MPT bidentate NN-chelate, water molecule, two thiocyanate groups cis positions to another. One acts bridging between metal centers, leading one-dimensional structure that extends along c-direction. other group terminally N-coordinated. has been screened vitro against pathogenic fungal strains: A. fumigatus, C. albican, four bacterial S. aureus, B. subtilis gram-positive bacteria, E. coli, P. vulgaris gram-negative bacteria. results showed potential be used both antibacterial antifungal agent. Also, cytotoxic activities hepatocellular (HepG-2) lung (A-549) cell lines, IC50 values 132.67 ± 5.14 146.97 7.34 μM, respectively.