A Neutralizing Antibody to the A Chain of Abrin Inhibits Abrin Toxicity both In Vitro and In Vivo
نویسندگان
چکیده
منابع مشابه
A neutralizing antibody to the a chain of abrin inhibits abrin toxicity both in vitro and in vivo.
Plant ribosome-inactivating proteins (RIPs) are RNA N-glycosidases that inhibit protein synthesis in cells. Abrin, a type II RIP, is an AB type toxin, which is one of the most lethal types of toxin known. The B chain facilitates the entry of the molecule into the cell, whereas the A chain exerts the toxic effect. We have generated hybridomas secreting antibodies of the immunoglobulin G class sp...
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ژورنال
عنوان ژورنال: Clinical and Vaccine Immunology
سال: 2008
ISSN: 1556-6811,1556-679X
DOI: 10.1128/cvi.00254-07