A Monte Carlo Approach for Estimation of Haplotype Probabilities in Half-Sib Families
نویسندگان
چکیده
منابع مشابه
Optimal haplotype reconstruction in half-sib families
In the goal of genetic improvement of livestock by marker assisted selection, we aim at reconstructing the haplotypes of sires from their offspring. We reformulated this problem into a binary weighted constraint satisfaction problem. Our results showed these problems have a small treewidth and can be solved optimally, improving haplotype reconstruction compared to previous approaches especially...
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Genome-wide estimated breeding values can be computed from the simultaneous estimates of the effects of small intervals of DNA throughout the genome on a trait or traits of interest. Small intervals or segments of DNA can be created by the use of thousands of single nucleotide polymorphisms (SNP) available in panels of 10, 25 and 50 thousand SNP. A simulation study was conducted to compare fact...
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Maximum likelihood methods for the estimation of linkage disequilibrium between biallelic DNA-markers in half-sib families (half-sib method) are developed for single and multifamily situations. Monte Carlo computer simulations were carried out for a variety of scenarios regarding sire genotypes, linkage disequilibrium, recombination fraction, family size, and number of families. A double hetero...
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ژورنال
عنوان ژورنال: Journal of Dairy Science
سال: 2004
ISSN: 0022-0302
DOI: 10.3168/jds.s0022-0302(04)73575-4