A monoclonal antibody against Echinococcus multilocularis Em2 antigen
نویسندگان
چکیده
منابع مشابه
Heterologous Immunization, a Way out of the Problem of Monoclonal Antibody Production against Carcinoma Antigen 125
Background: Monoclonal antibodies (mAbs) are essential tools for many molecular im-munology investigations, epitope mapping and molecular modelling, clinical laboratory di-agnostic tests and immunotherapy. Humoral immune response of immunized animals largely depends on the nature of antigen and the immunization technique. Polysaccharides and heavily-glycosylated proteins are very elusive target...
متن کاملA major Echinococcus multilocularis antigen is a mucin-type glycoprotein.
The metacestode of Echinococcus multilocularis is surrounded by a carbohydrate-rich laminated layer, which plays a key role in the establishment of the infection in the mammalian host. A major component of the laminated layer is an antigen referred to as Em2(G11). This highly species-specific antigen has been used for serodiagnoses of alveolar echinococcosis and is suggested to contain carbohyd...
متن کاملMolecular cloning of a vaccine antigen against infection with the larval stage of Echinococcus multilocularis.
Alveolar and cystic hydatidosis are caused by infection with the larval stages of Echinococcus multilocularis and Echinococcus granulosus, respectively. A host-protective antigen has been identified in E. granulosus. Here we identify the presence of a closely related protein in E. multilocularis, characterize and express a cDNA encoding the antigen (designated EM95), determine the structure of ...
متن کاملEchinococcus multilocularis in Estonia
To the Editor: Alveolar echinoco-ccosis (AE) caused by Echinococcus multilocularis is one of the most important emerging zoonosis in Europe. The fatality rate is >90% in untreated patients (1). In Europe, the distribution range of the zoonotic tapeworm E. multilocularis has expanded over the last few decades, and the parasite attracts increasing awareness as a public health issue (2–5). In 2003...
متن کاملDevelopment of a monoclonal antibody against a tumor-associated antigen.
A monoclonal antibody-producing hybrid cell line was obtained by fusing mouse myeloma cells with spleen cells from a mouse immunized with C6 glioma cells. This antibody binds to a specific cell-surface antigen that is present on C6 rat glioma cells, transformed astrocytes and oligodendrocytes, and a human glioma cell line but is absent on a normal glial cell line, fibroblasts, and primary cultu...
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ژورنال
عنوان ژورنال: Parasitology
سال: 1991
ISSN: 0031-1820,1469-8161
DOI: 10.1017/s0031182000059278