A molecular signature for delayed graft function
نویسندگان
چکیده
منابع مشابه
Delayed Graft Function
Delayed graft function (DGF) is a common complication of renal transplantation. According to a clinical data analysis of 34,647 cases of cadaveric renal transplantation documented by the Renal Transplantation Registry of the United Network Sharing (UNOS), graft function did not recover instantly after transplantation and for ever in some cases; the 1-year rate of graft loss was up to 20% in cas...
متن کاملBuMPy road of delayed graft function.
DELAYED GRAFT FUNCTION (DGF) occurs in 20–30% of renal transplants and contributes significantly to the gradual loss of grafts through accelerated development of chronic allograft dysfunction. Members of the transforming growth factor(TGF) family are incriminated as the major driving force for developing fibrosis. In an issue of the American Journal of Physiology-Renal Physiology, Simone and co...
متن کاملPredictive Values of Urinary Interleukin 18 and Neutrophil Gelatinase-Associated Lipocalin for Delayed Graft Function Diagnosis in Kidney Transplantation
Background: Delayed graft function is a main complication after deceased donor kidney transplantation that adversely affects graft outcome. Difficulties in prediction and early detection of delayed graft function have hindered the ability to perform proper therapeutic interventions. We investigated whether measuring urinary interleukin 18 and neutrophi...
متن کاملImpact of delayed graft function on renal function and graft survival in deceased kidney transplantation.
OBJECTIVES To define the risk factors for delayed graft function and study the impact of such delays on renal function and long-term allograft survival in renal transplant recipients. DESIGN Single-centre retrospective study. SETTING Regional hospital, Hong Kong. PATIENTS Records of 118 Chinese renal transplant recipients from 1 July 1997 to 31 July 2005 were reviewed, and categorised int...
متن کاملIdentification of Molecular Markers of Delayed Graft Function Based on the Regulation of Biological Ageing.
INTRODUCTION Delayed graft function is a prevalent clinical problem in renal transplantation for which there is no objective system to predict occurrence in advance. It can result in a significant increase in the necessity for hospitalisation post-transplant and is a significant risk factor for other post-transplant complications. METHODOLOGY The importance of microRNAs (miRNAs), a specific s...
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ژورنال
عنوان ژورنال: Aging Cell
سال: 2018
ISSN: 1474-9718
DOI: 10.1111/acel.12825