A Mini-Review 5-Amino-N-Substituted Pyrazoles as Building Blocks for Bioactive Molecules
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چکیده
منابع مشابه
Enaminones as building blocks for the synthesis of substituted pyrazoles with antitumor and antimicrobial activities.
Novel N-arylpyrazole-containing enaminones 2a,b were synthesized as key intermediates. Reactions of 2a,b with active methylene compounds in acetic acid in the presence of ammonium acetate afforded substituted pyridine derivatives 5a-d. Enaminones 2a,b also reacted with aliphatic amines such as hydrazine hydrate and hydroxylamine hydrochloride to give bipyrazoles 8a,b and pyrazolylisoxazoles 9a,...
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offers many advantages as newly designed drugs. The benefits include enhanced stability to proteolytic enzymes, better transport through cellular membranes, increased bio-availability, changing agonist to antagonists potency and higher affinity in ligand-receptors interactions. D-amino acids are used to design and obtain new peptidomimetics by their incorporation in place of the natural L-amino...
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ژورنال
عنوان ژورنال: International Journal of Organic Chemistry
سال: 2020
ISSN: 2161-4687,2161-4695
DOI: 10.4236/ijoc.2020.102004